The opening animation features the song “Muttsu-ko no Tamashii Nayuta Made” (“The Souls of Six Children, Until 10^60”), which is performed by AOP.
The series features a set of sextuplets, the Matsuno brothers, with Osomatsu being the oldest brother and leader of the group.
The ending animation features the song “Amazing Intelligence~Guzu wa Saiko!!!!!!!!!!!!!♡♡△△~” (“Amazing Intelligence – Trash is Best!!!!!!!!!!!!!♡♡△△~”), which is performed by Omusubi with Osomatsu-san All Stars.