The Karakai Jōzu no Takagi-san manga centers on Nishikata, a middle school student who has suffered humiliation due to being teased by Takagi, the girl who sits next to him.
Yamamoto launched the Karakai Jōzu no Takagi-san manga in Gessan mini, the accompanying booklet to the main Gessan magazine, in 2013.
After Yamamoto finished serializing his Fudatsuki no Kyōko-chan manga in Gessan in June 2016, Karakai Jōzu no Takagi-san moved to Gessan in July.
Hiroaki Akagi (Hina Logic – from Luck & Logic) is directing Karakai Jōzu no Takagi-san at Shinei Animation (Elegant Yokai Apartment Life, Doraemon).