The Japanese cast includes Tomoaki Maeno as White Blood Cell (Neutrophil), Kana Hanazawa as Red Blood Cell (Erythrocite), Kikuko Inoue as Macrophage, Daisuke Ono as Killer T Cell, Maria Naganawa as Platelet, Takahiro Sakurai as Helper T Cell (T Lymphocyte), Saori Hayami as Regulatory T Cell, M.A.
The second season of the series will be directed by Hirofumi Ogura while the rest of the main staff remains the same.
The summer 2018 anime series Cells at Work announced previously that a second season was in the work amid a few other projects.
The first series was directed by Kenichi Suzuki based on the series composition by Yuuko Kakihara.