The hotel is one of several adjacent to the San Jose McEnery Convention Center where Crunchyroll Expo is currently taking place this weekend.
San Jose Fire Department Captain Mitch Matlow told The Mercury News that the injuries were not believed to be life-threatening.
The local fire department arrived at the hotel at approximately 10 a.m. after staff discovered a woman deceased on the 19th floor and smelled a chemical odor.
The Hotel Farimont in San Jose, California has evacuated three floors after a chemical used in an apparent suicide also sickened several employees and guests.