Oku previously directed the 2017 Asura Girl ~Blood-C Ibun~ live-action film and the 2015 Blood-C: The Last Mind stage play, while Fujisaku wrote the scripts for the 2011 television anime and the stage play adaptation.
Keisuke Minami, who also appeared in the Blood-C: The Last Mind stage play), will also star in the film.
Manga creator team CLAMP developed the story and original character designs for both the 2011 Blood-C television series and its anime film sequel, titled Blood-C: The Last Dark.
Amazon Prime is streaming the Blood-C: The Last Mind stage play.