Katsuhiko Manabe (Shin Kyūseishu Densetsu Hokuto no Ken: Raoh-den Gekitō no Shō, Shin Kyūseishu Densetsu Hokuto no Ken: Raoh-den Junai no Shō) and Kensaku Kojima (live-action Shinya Shokudō series) both oversaw and wrote the scripts, and mabanua (Kids on the Slope) composed the music.
The 13-episode anime premiered on TBS on April 5, and Crunchyroll streamed the series as it aired.
The LA Femme Film Festival announced on September 27 that it will screen episodes of the Megalobox anime at the Regal Cinema at LA Live in Los Angeles on October 12, with show producer Minako Fujiyoshi in attendance for a Q&A panel after the screening.
The anime celebrates the 50th anniversary of Ikki Kajiwara (pen name Asao Takamori) and Tetsuya Chiba’s Ashita no Joe manga, and it features an original story.