In the world of bizarro game creators, Suda51 (No More Heroes) and Swery65 (Deadly Premonition) seem like they’d go together like peanut butter and jelly.
As for the title, Suda51 apparently came up with it about half an hour before the stream.
Inspirations include 2004 horror game Siren, David Lynch, and the third season of Twin Peaks, which Swery attributes to the fact that these all center on “suspense, uncertainty, and nervousness.”