The story of Musume Janakute Mama ga Sukinano!? follows Ayako Katsuragi (voiced by Kayano), a 30-something housewife who adopted her deceased sister’s daughter, Miu, some ten years ago and raised Miu as her own.
Miu is now in high school, and Miu’s childhood friend and nextdoor neighbor, Takumi Aterazawa (voiced by Shimazaki), has just entered college.