The story follows Ryuichi Kashima and his infant brother, Kotaro, who are orphaned when their parents die in a plane crash.
The two brothers are taken in by Yoko Morinomiya, the director of a children’s academy who lost her adult son and her daughter-in-law in the same plane crash.
The original Gakuen Babysitters manga is serialized in Hakusensha’s LaLa shōjo manga mangazine.